2-O, 3-O-Desulfated Heparin Inhibits Neutrophil Elastase–Induced HMGB-1 Secretion and Airway Inflammation

Neutrophil elastase (NE) is a major inflammatory mediator in cystic fibrosis (CF) that is a robust predictor of lung disease progression. NE directly causes airway injury via protease activity, and propagates persistent neutrophilic inflammation by up-regulation of neutrophil chemokine expression. D...

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Main Authors: Griffin, Kathryn L., Fischer, Bernard M., Kummarapurugu, Apparao B., Zheng, Shuo, Kennedy, Thomas P., Rao, Narayanam V., Foster, W. Michael, Voynow, Judith A.
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2014
Assuntos:
Rapid Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068925/
https://ncbi.nlm.nih.gov/pubmed/24325600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0338RC
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