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Glycosaminoglycans as Multifunctional Anti-Elastase and Anti-Inflammatory Drugs in Cystic Fibrosis Lung Disease

Neutrophil elastase (NE) is a major protease in the airways of patients with cystic fibrosis (CF) that activates airway inflammation by several mechanisms. NE stimulates epithelial toll like receptors (TLR) resulting in cytokine upregulation and release, upregulates MUC5AC, a major airway mucin, deg...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Voynow, Judith A., Zheng, Shuo, Kummarapurugu, Apparao B.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360816/
https://ncbi.nlm.nih.gov/pubmed/32733248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01011
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