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Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase
Altered sphingolipid metabolism is associated with increased inflammation; however, the impact of inflammatory mediators, including neutrophil elastase (NE), on airway sphingolipid homeostasis remains unknown. Using a well-characterized mouse model of NE oropharyngeal aspiration, we investigated a p...
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| Published in: | Am J Physiol Lung Cell Mol Physiol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Physiological Society
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5866429/ https://ncbi.nlm.nih.gov/pubmed/29025713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00322.2017 |
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