Neutrophil Elastase Increases Airway Epithelial Nonheme Iron Levels

Alpha‐1‐antitrypsin (A1AT) deficiency is characterized by increased neutrophil elastase (NE) activity and oxidative stress in the lung. We hypothesized that NE exposure generates reactive oxygen species by increasing lung nonheme iron. To test this hypothesis, we measured bronchoalveolar lavage (BAL...

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Autors principals: Fischer, Bernard M., Domowicz, Denise A. Lopez, Zheng, Shuo, Carter, Jamie L., McElvaney, N. Gerry, Taggart, Clifford, Lehmann, James R., Voynow, Judith A., Ghio, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Inc 2009
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857349/
https://ncbi.nlm.nih.gov/pubmed/20411049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1752-8062.2009.00151.x
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