Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses

BACKGROUND: Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation in allergen-induced airway responses is not well defined...

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Autors principals: Koga, Hikari, Miyahara, Nobuaki, Fuchimoto, Yasuko, Ikeda, Genyo, Waseda, Koichi, Ono, Katsuichiro, Tanimoto, Yasushi, Kataoka, Mikio, Gelfand, Erwin W, Tanimoto, Mitsune, Kanehiro, Arihiko
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570429/
https://ncbi.nlm.nih.gov/pubmed/23347423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-8
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