CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET

Asthma is characterized by airway inflammation and remodeling and CXCL8 is a CXC chemokine that drives steroid-resistant neutrophilic airway inflammation. We have shown that airway smooth muscle (ASM) cells isolated from asthmatic individuals secrete more CXCL8 than cells from nonasthmatic individua...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Clifford, Rachel L., Patel, Jamie K., John, Alison E., Tatler, Amanda L., Mazengarb, Lisa, Brightling, Christopher E., Knox, Alan J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421784/
https://ncbi.nlm.nih.gov/pubmed/25713319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00021.2015
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