Human Airway Smooth Muscle Cells from Asthmatic Individuals Have CXCL8 Hypersecretion Due to Increased NF-κB p65, C/EBPβ, and RNA Polymerase II Binding to the CXCL8 Promoter

CXCL8 is a neutrophil and mast cell chemoattractant that is involved in regulating inflammatory cell influx in asthma. Here, we investigated the transcriptional mechanism involved in CXCL8 induction by TNF-α in cultured human airway smooth muscle (HASM) cells and compared these in cells from nonasth...

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Hlavní autoři: John, Alison E., Zhu, Yong M., Brightling, Christopher E., Pang, Linhua, Knox, Alan J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992371/
https://ncbi.nlm.nih.gov/pubmed/19734226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803832
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