Mitochondrial Ca(2+) Uniporter is a Mitochondrial Luminal Redox Sensor That Augments MCU Channel Activity

Ca(2+) dynamics and oxidative signaling are fundamental mechanisms for mitochondrial bioenergetics and cell function. The MCU complex is the major pathway by which these signals are integrated in mitochondria. Whether and how these coactive elements interact with MCU has not been established. As an...

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Publicado en:Mol Cell
Main Authors: Dong, Zhiwei, Shanmughapriya, Santhanam, Tomar, Dhanendra, Siddiqui, Naveed, Lynch, Solomon, Nemani, Neeharika, Breves, Sarah L., Zhang, Xueqian, Tripathi, Aparna, Palaniappan, Palaniappan, Riitano, Massimo F., Worth, Alison, Seelam, Ajay, Carvalho, Edmund, Subbiah, Ramasamy, Jaña, Fabián, Soboloff, Jonathan, Peng, Yizhi, Cheung, Joseph Y., Joseph, Suresh K., Caplan, Jeffrey, Rajan, Sudarsan, Stathopulos, Peter B., Madesh, Muniswamy
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357178/
https://ncbi.nlm.nih.gov/pubmed/28262504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.032
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