The development of novel LTA(4)H modulators to selectively target LTB(4) generation

The pro-inflammatory mediator leukotriene B(4) (LTB(4)) is implicated in the pathologies of an array of diseases and thus represents an attractive therapeutic target. The enzyme leukotriene A(4) hydrolase (LTA(4)H) catalyses the distal step in LTB(4) synthesis and hence inhibitors of this enzyme hav...

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Publicat a:Sci Rep
Autors principals: Low, Caroline M., Akthar, Samia, Patel, Dhiren F., Löser, Stephan, Wong, Chi-Tung, Jackson, Patricia L., Blalock, J. Edwin, Hare, Stephen A., Lloyd, Clare M., Snelgrove, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355877/
https://ncbi.nlm.nih.gov/pubmed/28303931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44449
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