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The development of novel LTA(4)H modulators to selectively target LTB(4) generation
The pro-inflammatory mediator leukotriene B(4) (LTB(4)) is implicated in the pathologies of an array of diseases and thus represents an attractive therapeutic target. The enzyme leukotriene A(4) hydrolase (LTA(4)H) catalyses the distal step in LTB(4) synthesis and hence inhibitors of this enzyme hav...
Uloženo v:
| Vydáno v: | Sci Rep |
|---|---|
| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5355877/ https://ncbi.nlm.nih.gov/pubmed/28303931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44449 |
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