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A critical role for LTA(4)H in limiting chronic pulmonary neutrophilic inflammation

Leukotriene A(4) Hydrolase (LTA(4)H) is a pro-inflammatory enzyme which generates the inflammatory mediator leukotriene B(4) (LTB(4)). LTA(4)H also possesses aminopeptidase activity with unknown substrate and physiological significance. We identified the neutrophil chemoattractant, Pro-Gly-Pro (PGP)...

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Bibliografiske detaljer
Main Authors: Snelgrove, Robert J., Jackson, Patricia L., Hardison, Matthew T., Noerager, Brett D., Kinloch, Andrew, Gaggar, Amit, Shastry, Suresh, Rowe, Steven M., Shim, Yun M., Hussell, Tracy, Blalock, J. Edwin
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072752/
https://ncbi.nlm.nih.gov/pubmed/20813919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1190594
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