Rescuing cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by transcomplementation

Por Cormet-Boyaka, Estelle, Jablonsky, Michael, Naren, Anjaparavanda P., Jackson, Patricia L., Muccio, Donald D., Kirk, Kevin L.
Publicado em 2004

N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD

Por O'Reilly, Philip, Jackson, Patricia L, Noerager, Brett, Parker, Suzanne, Dransfield, Mark, Gaggar, Amit, Blalock, J Edwin
Publicado em 2009

A Self-Propagating Matrix Metalloprotease-9 (MMP-9) Dependent Cycle of Chronic Neutrophilic Inflammation

Por Xu, Xin, Jackson, Patricia L., Tanner, Scott, Hardison, Matthew T., Abdul Roda, Mojtaba, Blalock, James Edwin, Gaggar, Amit
Publicado em 2011

MMP-9 Cleaves SP-D and Abrogates Its Innate Immune Functions In Vitro

Por Bratcher, Preston E., Weathington, Nathaniel M., Nick, Heidi J., Jackson, Patricia L., Snelgrove, Robert J., Gaggar, Amit
Publicado em 2012

Human Neutrophil Elastase-Mediated Cleavage Sites of MMP-9 and TIMP-1: Implications to Cystic Fibrosis Proteolytic Dysfunction

Por Jackson, Patricia L, Xu, Xin, Wilson, Landon, Weathington, Nathaniel M, Clancy, John Paul, Blalock, James Edwin, Gaggar, Amit
Publicado em 2010

Sputum PGP is reduced by azithromycin treatment in patients with COPD and correlates with exacerbations

Por O'Reilly, Philip J, Jackson, Patricia L, Wells, J Michael, Dransfield, Mark T, Scanlon, Paul D, Blalock, J Edwin
Publicado em 2013

Microbicidal Activity of Vascular Peroxidase 1 in Human Plasma via Generation of Hypochlorous Acid

Por Li, Hong, Cao, Zehong, Moore, D. Ray, Jackson, Patricia L., Barnes, Stephen, Lambeth, J. David, Thannickal, Victor J., Cheng, Guangjie
Publicado em 2012

NEUTROPHILS CONTAIN PROLYL ENDOPEPTIDASE AND GENERATE THE CHEMOTACTIC PEPTIDE, PGP, FROM COLLAGEN

Por O'Reilly, Philip J., Hardison, Matthew T., Jackson, Patricia L., Xu, Xin, Snelgrove, Robert J., Gaggar, Amit, Galin, F. Shawn, Blalock, J. Edwin
Publicado em 2009

Possible Therapeutic Vaccines for Canine Myasthenia Gravis: Implications for the Human Disease and Associated Fatigue

Por Galin, F. Shawn, Chrisman, Cheryl L., Cook, James R., Xu, Likang, Jackson, Patricia L., Noerager, Brett D., Weathington, Nathaniel M., Blalock, J. Edwin
Publicado em 2006

Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown

Por Braber, Saskia, Koelink, Pim J., Henricks, Paul A. J., Jackson, Patricia L., Nijkamp, Frans P., Garssen, Johan, Kraneveld, Aletta D., Blalock, J. Edwin, Folkerts, Gert
Publicado em 2011

A CXCL8 receptor antagonist based on the structure of N-Acetyl-Proline-Glycine-Proline

Por Jackson, Patricia L., Noerager, Brett D., Jablonsky, Michael J., Hardison, Matthew T., Cox, Bryan D., Patterson, James C., Dhanapal, Boopathy, Blalock, J. Edwin, Muccio, Donald D.
Publicado em 2011

A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation(,)

Por Gaggar, Amit, Jackson, Patricia L., Noerager, Brett D., O’Reilly, Philip J., McQuaid, D. Brent, Rowe, Steven M., Clancy, J. P., Blalock, J. Edwin
Publicado em 2008

Targeting Prolyl Endopeptidase with Valproic Acid as a Potential Modulator of Neutrophilic Inflammation

Por Abdul Roda, Mojtaba, Sadik, Mariam, Gaggar, Amit, Hardison, Matthew T., Jablonsky, Michael J., Braber, Saskia, Blalock, James Edwin, Redegeld, Frank A., Folkerts, Gert, Jackson, Patricia L.
Publicado em 2014

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection

Por Akthar, Samia, Patel, Dhiren F., Beale, Rebecca C., Peiró, Teresa, Xu, Xin, Gaggar, Amit, Jackson, Patricia L., Blalock, J. Edwin, Lloyd, Clare M., Snelgrove, Robert J.
Publicado no Nat Commun (2015)

A critical role for LTA(4)H in limiting chronic pulmonary neutrophilic inflammation

Por Snelgrove, Robert J., Jackson, Patricia L., Hardison, Matthew T., Noerager, Brett D., Kinloch, Andrew, Gaggar, Amit, Shastry, Suresh, Rowe, Steven M., Shim, Yun M., Hussell, Tracy, Blalock, J. Edwin
Publicado em 2010

An Active Role for Matrix Degradation in Airway Inflammation Seen During Lung Transplantation Allograft Rejection

Por Hardison, Matthew T., Galin, F. Shawn, Calderon, Christopher E., Djekic, Uros V., Parker, Suzanne B., Wille, Keith M., Jackson, Patricia L., Young, K. Randall, Blalock, J. Edwin, Gaggar, Amit
Publicado no J Immunol (2009)

The development of novel LTA(4)H modulators to selectively target LTB(4) generation

Por Low, Caroline M., Akthar, Samia, Patel, Dhiren F., Löser, Stephan, Wong, Chi-Tung, Jackson, Patricia L., Blalock, J. Edwin, Hare, Stephen A., Lloyd, Clare M., Snelgrove, Robert J.
Publicado no Sci Rep (2017)

A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease

Por Wells, J. Michael, Jackson, Patricia L., Viera, Liliana, Bhatt, Surya P., Gautney, Joshua, Handley, Guy, King, R. Wilson, Xu, Xin, Gaggar, Amit, Bailey, William C., Dransfield, Mark T., Blalock, J. Edwin
Publicado no Am J Respir Crit Care Med (2015)

Potential Role of High-Mobility Group Box 1 in Cystic Fibrosis Airway Disease

Por Rowe, Steven M., Jackson, Patricia L., Liu, Gang, Hardison, Mathew, Livraghi, Alessandra, Solomon, G. Martin, McQuaid, D. Brent, Noerager, Brett D., Gaggar, Amit, Clancy, J. P., O'Neal, Wanda, Sorscher, Eric J., Abraham, Edward, Blalock, J. Edwin
Publicado em 2008

Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?

Por Overbeek, Saskia A., Braber, Saskia, Koelink, Pim J., Henricks, Paul A. J., Mortaz, Esmaeil, LoTam Loi, Adele T., Jackson, Patricia L., Garssen, Johan, Wagenaar, Gerry T. M., Timens, Wim, Koenderman, Leo, Blalock, J. Edwin, Kraneveld, Aletta D., Folkerts, Gert
Publicado em 2013