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NEUTROPHILS CONTAIN PROLYL ENDOPEPTIDASE AND GENERATE THE CHEMOTACTIC PEPTIDE, PGP, FROM COLLAGEN

Prolyl endopeptidase (PE), a protease that cleaves after proline residues in oligopeptides, is highly active in brain and degrades neuropeptides in vitro. We have recently demonstrated that PE, in concert with MMP's, can generate PGP (prolineglycine-proline), a novel, neutrophil chemoattractant...

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Detalhes bibliográficos
Main Authors: O'Reilly, Philip J., Hardison, Matthew T., Jackson, Patricia L., Xu, Xin, Snelgrove, Robert J., Gaggar, Amit, Galin, F. Shawn, Blalock, J. Edwin
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787998/
https://ncbi.nlm.nih.gov/pubmed/19875179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2009.09.020
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