A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease

Rationale: Roflumilast is a therapeutic agent in the treatment of chronic obstructive pulmonary disease (COPD). It has antiinflammatory effects; however, it is not known whether it can affect a biologic pathway implicated in COPD pathogenesis and progression. The self-propagating acetyl-proline-glyc...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Wells, J. Michael, Jackson, Patricia L., Viera, Liliana, Bhatt, Surya P., Gautney, Joshua, Handley, Guy, King, R. Wilson, Xu, Xin, Gaggar, Amit, Bailey, William C., Dransfield, Mark T., Blalock, J. Edwin
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642210/
https://ncbi.nlm.nih.gov/pubmed/26151090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201503-0543OC
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