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The development of novel LTA(4)H modulators to selectively target LTB(4) generation
The pro-inflammatory mediator leukotriene B(4) (LTB(4)) is implicated in the pathologies of an array of diseases and thus represents an attractive therapeutic target. The enzyme leukotriene A(4) hydrolase (LTA(4)H) catalyses the distal step in LTB(4) synthesis and hence inhibitors of this enzyme hav...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5355877/ https://ncbi.nlm.nih.gov/pubmed/28303931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44449 |
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