Protein Transduction Domains Fused to Virus Receptors Improve Cellular Virus Uptake and Enhance Oncolysis by Tumor-Specific Replicating Vectors

Expression of cellular receptors determines viral tropism and limits gene delivery by viral vectors. Protein transduction domains (PTDs) have been shown to deliver proteins, antisense oligonucleotides, liposomes, or plasmid DNA into cells. In our study, we investigated the role of several PTD motifs...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kühnel, Florian, Schulte, Bernd, Wirth, Thomas, Woller, Norman, Schäfers, Sonja, Zender, Lars, Manns, Michael, Kubicka, Stefan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Gene Therapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC533898/
https://ncbi.nlm.nih.gov/pubmed/15564483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.24.13743-13754.2004
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