Meganuclease-mediated Virus Self-cleavage Facilitates Tumor-specific Virus Replication

Meganucleases can specifically cleave long DNA sequence motifs, a feature that makes them an ideal tool for gene engineering in living cells. In a proof-of-concept study, we investigated the use of the meganuclease I-Sce I for targeted virus self-disruption to generate high-specific oncolytic viruse...

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Detalhes bibliográficos
Main Authors: Gürlevik, Engin, Schache, Peter, Goez, Anneliese, Kloos, Arnold, Woller, Norman, Armbrecht, Nina, Manns, Michael P, Kubicka, Stefan, Kühnel, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776629/
https://ncbi.nlm.nih.gov/pubmed/23752311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.117
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