Selectivity of Oncolytic Viral Replication Prevents Antiviral Immune Response and Toxicity, but Does Not Improve Antitumoral Immunity

Oncolytic infection elicits antitumoral immunity, but the impact of tumor-selective replication on the balance between antiviral and antitumoral immune responses has not yet been investigated. To address this question, we constructed the highly tumor-selective adenovirus Ad-p53T whose replication in...

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Bibliografske podrobnosti
Main Authors: Gürlevik, Engin, Woller, Norman, Strüver, Nina, Schache, Peter, Kloos, Arnold, Manns, Michael P, Zender, Lars, Kühnel, Florian, Kubicka, Stefan
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990511/
https://ncbi.nlm.nih.gov/pubmed/20700112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.163
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