Targeting of p53-Transcriptional Dysfunction by Conditionally Replicating Adenovirus Is Not Limited by p53-Homologues

A hallmark of human tumors is the loss of p53 or its transcriptional functions. In this study, we describe the generation of the conditionally replicating adenovirus Adp53sensor for the treatment of p53-dysfunctional tumors. p53-selective attenuation of viral replication was achieved by using p53-de...

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Autores principales: Kühnel, Florian, Gürlevik, Engin, Wirth, Thomas C, Strüver, Nina, Malek, Nisar P, Müller-Schilling, Martina, Manns, Michael P, Carnero, Amancio, Zender, Lars, Kubicka, Stefan
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2009
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890106/
https://ncbi.nlm.nih.gov/pubmed/20040911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.298
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