p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication

RNA-interference (RNAi) is a potent tool for specific gene silencing. In this study, we developed an adenovirus for conditional replication in p53-dysfunctional tumor cells that uses p53-selective expression of a microRNA-network directed against essential adenoviral genes. Compared to a control vir...

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Autors principals: Gürlevik, Engin, Woller, Norman, Schache, Peter, Malek, Nisar P., Wirth, Thomas C., Zender, Lars, Manns, Michael P., Kubicka, Stefan, Kühnel, Florian
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2009
Matèries:
Methods Online
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709585/
https://ncbi.nlm.nih.gov/pubmed/19443444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp374
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