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p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication
RNA-interference (RNAi) is a potent tool for specific gene silencing. In this study, we developed an adenovirus for conditional replication in p53-dysfunctional tumor cells that uses p53-selective expression of a microRNA-network directed against essential adenoviral genes. Compared to a control vir...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2709585/ https://ncbi.nlm.nih.gov/pubmed/19443444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp374 |
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