Discovery of Macrocyclic Pyrimidines as MerTK-specific Inhibitors

Macrocycles have attracted significant attention in drug discovery recently. In fact, a few de novo designed macrocyclic kinases inhibitors are currently in clinical trials with good potency and selectivity for their intended target. In this paper, we have successfully engaged a structure-based drug...

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Veröffentlicht in:ChemMedChem
Hauptverfasser: McIver, Andrew L., Zhang, Weihe, Liu, Qingyang, Jiang, Xinpeng, Stashko, Michael A., Nichols, James, Miley, Michael J, Norris-Drouin, Jacqueline, Machius, Mischa, DeRyckere, Deborah, Wood, Edgar, Graham, Douglas K., Earp, H Shelton, Kireev, Dmitri, Frye, Stephen V., Wang, Xiaodong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336325/
https://ncbi.nlm.nih.gov/pubmed/28032464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600589
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