MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

MerTK, a receptor tyrosine kinase (RTK) of the TYRO3/AXL/MerTK family, is expressed in myeloid lineage cells in which it acts to suppress proinflammatory cytokines following ingestion of apoptotic material. Using syngeneic mouse models of breast cancer, melanoma, and colon cancer, we found that tumo...

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Detalhes bibliográficos
Main Authors: Cook, Rebecca S., Jacobsen, Kristen M., Wofford, Anne M., DeRyckere, Deborah, Stanford, Jamie, Prieto, Anne L., Redente, Elizabeth, Sandahl, Melissa, Hunter, Debra M., Strunk, Karen E., Graham, Douglas K., Earp, H. Shelton
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726162/
https://ncbi.nlm.nih.gov/pubmed/23867499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67655
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