MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

MerTK, a receptor tyrosine kinase (RTK) of the TYRO3/AXL/MerTK family, is expressed in myeloid lineage cells in which it acts to suppress proinflammatory cytokines following ingestion of apoptotic material. Using syngeneic mouse models of breast cancer, melanoma, and colon cancer, we found that tumo...

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Hauptverfasser: Cook, Rebecca S., Jacobsen, Kristen M., Wofford, Anne M., DeRyckere, Deborah, Stanford, Jamie, Prieto, Anne L., Redente, Elizabeth, Sandahl, Melissa, Hunter, Debra M., Strunk, Karen E., Graham, Douglas K., Earp, H. Shelton
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726162/
https://ncbi.nlm.nih.gov/pubmed/23867499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67655
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