TMIC-32. INHIBITION OF MerTK MODULATES GLIOMA-ASSOCIATED MACROPHAGES AND MICROGLIA IN TUMOR MICROENVIRONMENT

BACKGROUND: Glioma-associated macrophages and microglia (GAMs) are predominant immune cells in a glioma microenvironment. Receptor tyrosine kinase MerTK is highly expressed in GAMs. Activation of MerTK triggers efferocytosis and polarizes GAMs to an immunosuppressive phenotype, promoting tumor growt...

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Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Su, Yu-Ting, Phan, Funita, Hwang, Lee, Earp, H Shelton, Gilbert, Mark, Wu, Jing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2018
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Abstracts
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216436/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1091
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