EXTH-44. INHIBITION OF MerTK ACTIVATES GLIOBLASTOMA-ASSOCIATED MACROPHAGES AND INDUCES TUMOR CELL DEATH IN GLIOMA MICROENVIRONMENT

BACKGROUND: Glioblastoma-associated macrophages and microglia (GAMs) are the predominant immune cells in the tumor microenvironment. Activation of MerTK, a receptor tyrosine kinase, triggers efferocytosis and polarizes GAMs to an immunosuppressive phenotype, promoting glioma growth. Our previous fin...

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發表在:Neuro Oncol
Main Authors: Su, Yu-Ting, Butler, Madison, Hwang, Lee, Maric, Dragan, Earp, Shelton, Terabe, Masaki, Gilbert, Mark, Wu, Jing
格式: Artigo
語言:Inglês
出版: Oxford University Press 2019
主題:
Experimental Therapeutics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847213/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.376
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