DMBA induced mouse mammary tumors display high incidence of activating Pik3ca(H1047) and loss of function Pten mutations

Controversy always existed on the utility of chemically induced mouse mammary carcinogenesis models as valid equivalents for the study of human breast cancer. Here, we performed whole exome and RNA sequencing on long latency mammary tumors (218 ± 27 days) induced by the carcinogen 7,12-Dimethylbenza...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Abba, Martín C., Zhong, Yi, Lee, Jaeho, Kil, Hyunsuk, Lu, Yue, Takata, Yoko, Simper, Melissa S., Gaddis, Sally, Shen, Jianjun, Aldaz, C. Marcelo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325442/
https://ncbi.nlm.nih.gov/pubmed/27588403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11733
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