DMBA induced mouse mammary tumors display high incidence of activating Pik3ca(H1047) and loss of function Pten mutations

Controversy always existed on the utility of chemically induced mouse mammary carcinogenesis models as valid equivalents for the study of human breast cancer. Here, we performed whole exome and RNA sequencing on long latency mammary tumors (218 ± 27 days) induced by the carcinogen 7,12-Dimethylbenza...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Abba, Martín C., Zhong, Yi, Lee, Jaeho, Kil, Hyunsuk, Lu, Yue, Takata, Yoko, Simper, Melissa S., Gaddis, Sally, Shen, Jianjun, Aldaz, C. Marcelo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325442/
https://ncbi.nlm.nih.gov/pubmed/27588403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11733
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