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Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation

PTEN loss and PIK3CA activation both promote the accumulation of phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3). While these proteins also have distinct biochemical functions, beyond the regulation of PIP3, little is known about the consequences of these differences in vivo. Here, we directly c...

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Publicat a:Oncotarget
Autors principals: Liu, Jeff C., Wang, Dong-Yu, Egan, Sean E., Zacksenhaus, Eldad
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891026/
https://ncbi.nlm.nih.gov/pubmed/26814435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6985
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