DMBA induced mouse mammary tumors display high incidence of activating Pik3ca(H1047) and loss of function Pten mutations

Controversy always existed on the utility of chemically induced mouse mammary carcinogenesis models as valid equivalents for the study of human breast cancer. Here, we performed whole exome and RNA sequencing on long latency mammary tumors (218 ± 27 days) induced by the carcinogen 7,12-Dimethylbenza...

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Опубликовано в: :Oncotarget
Главные авторы: Abba, Martín C., Zhong, Yi, Lee, Jaeho, Kil, Hyunsuk, Lu, Yue, Takata, Yoko, Simper, Melissa S., Gaddis, Sally, Shen, Jianjun, Aldaz, C. Marcelo
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325442/
https://ncbi.nlm.nih.gov/pubmed/27588403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11733
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