Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R

The phosphoinositide 3-kinase (PI3K) signaling cascade is a key mediator of cellular growth, survival and metabolism and is frequently subverted in human cancer. The gene encoding for the alpha catalytic subunit of PI3K (PIK3CA) is mutated and/or amplified in ∼30% of breast cancers. Mutations in eit...

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Detalhes bibliográficos
Main Authors: Meyer, D S, Koren, S, Leroy, C, Brinkhaus, H, Müller, U, Klebba, I, Müller, M, Cardiff, R D, Bentires-Alj, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816227/
https://ncbi.nlm.nih.gov/pubmed/24080956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2013.38
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