Physiological Levels of Pik3ca (H1047R) Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ERα-Positive Tumors

PIK3CA, the gene coding for the p110α subunit of phosphoinositide 3-kinase, is frequently mutated in a variety of human tumors including breast cancers. To better understand the role of mutant PIK3CA in the initiation and/or progression of breast cancer, we have generated mice with a conditional kno...

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Detalhes bibliográficos
Main Authors: Tikoo, Anjali, Roh, Vincent, Montgomery, Karen G., Ivetac, Ivan, Waring, Paul, Pelzer, Rebecca, Hare, Lauren, Shackleton, Mark, Humbert, Patrick, Phillips, Wayne A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364244/
https://ncbi.nlm.nih.gov/pubmed/22666336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036924
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