A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

Humanized mice are a powerful tool for the study of human hematopoiesis and immune function in vivo. However, the existing models cannot support robust adaptive immune responses, especially the generation of class-switched, antigen-specific antibody responses. Here we describe a new mouse strain, in...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Yu, Hua, Borsotti, Chiara, Schickel, Jean-Nicolas, Zhu, Shu, Strowig, Till, Eynon, Elizabeth E., Frleta, Davor, Gurer, Cagan, Murphy, Andrew J., Yancopoulos, George D., Meffre, Eric, Manz, Markus G., Flavell, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324713/
https://ncbi.nlm.nih.gov/pubmed/28077418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-709584
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