Humanized mouse model supports development, function, and tissue residency of human natural killer cells

Immunodeficient mice reconstituted with a human immune system represent a promising tool for translational research as they may allow modeling and therapy of human diseases in vivo. However, insufficient development and function of human natural killer (NK) cells and T cell subsets limit the applica...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Herndler-Brandstetter, Dietmar, Shan, Liang, Yao, Yi, Stecher, Carmen, Plajer, Valerie, Lietzenmayer, Melanie, Strowig, Till, de Zoete, Marcel R., Palm, Noah W., Chen, Jie, Blish, Catherine A., Frleta, Davor, Gurer, Cagan, Macdonald, Lynn E., Murphy, Andrew J., Yancopoulos, George D., Montgomery, Ruth R., Flavell, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692533/
https://ncbi.nlm.nih.gov/pubmed/29078283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705301114
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