Transgenic expression of human signal regulatory protein alpha in Rag2(−/−)γ(c)(−/−) mice improves engraftment of human hematopoietic cells in humanized mice

Transplantation of human hematopoietic stem cells into severely immunocompromised newborn mice allows the development of a human hematopoietic and immune system in vivo. NOD/scid/γ(c)(−/−) (NSG) and BALB/c Rag2(−/−)γ(c)(−/−) mice are the most commonly used mouse strains for this purpose and a number...

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Detalhes bibliográficos
Main Authors: Strowig, Till, Rongvaux, Anthony, Rathinam, Chozhavendan, Takizawa, Hitoshi, Borsotti, Chiara, Philbrick, William, Eynon, Elizabeth E., Manz, Markus G., Flavell, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156175/
https://ncbi.nlm.nih.gov/pubmed/21788509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109769108
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