Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

Mice with a functional human immune system have the potential to allow in vivo studies of human infectious diseases and to enable vaccine testing. To this end, mice need to fully support the development of human immune cells, allow infection with human pathogens, and be capable of mounting effective...

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Autors principals: Willinger, Tim, Rongvaux, Anthony, Takizawa, Hitoshi, Yancopoulos, George D., Valenzuela, David M., Murphy, Andrew J., Auerbach, Wojtek, Eynon, Elizabeth E., Stevens, Sean, Manz, Markus G., Flavell, Richard A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038773/
https://ncbi.nlm.nih.gov/pubmed/21262803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019682108
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