Microenvironment-dependent growth of pre-neoplastic and malignant plasma cells in humanized mice

Most human cancers including myeloma are preceded by a precursor state. There is an unmet need for in vivo models to study the interaction of human preneoplastic cells in the bone marrow microenvironment with non-malignant cells. Here, we genetically humanized mice to permit the growth of primary hu...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Das, Rituparna, Strowig, Till, Verma, Rakesh, Koduru, Srinivas, Hafemann, Anja, Hopf, Stephanie, Kocoglu, Mehmet H., Borsotti, Chiara, Zhang, Lin, Branagan, Andrew, Eynon, Elizabeth, Manz, Markus G., Flavell, Richard A., Dhodapkar, Madhav V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101153/
https://ncbi.nlm.nih.gov/pubmed/27723723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4202
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