Enzymatic activity and thermodynamic stability of biliverdin IXβ reductase are maintained by an active site serine

Biliverdin reductase IXβ (BLVRB) is a crucial enzyme in heme metabolism. Recent studies in humans have identified a loss-of-function mutation (Ser111Leu) that unmasks a fundamentally important role in hematopoiesis. We have applied experimental and thermodynamic modeling studies to provide further i...

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Pubblicato in:Chemistry
Autori principali: Chu, Wen-Ting, Nesbitt, Natasha M., Gnatenko, Dmitri V., Li, Zongdong, Zhang, Beibei, Seeliger, Markus A., Browne, Seamus, Mantle, Timothy J., Bahou, Wadie F., Wang, Jin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293602/
https://ncbi.nlm.nih.gov/pubmed/27897348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201604517
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