Enzymatic activity and thermodynamic stability of biliverdin IXβ reductase are maintained by an active site serine

Biliverdin reductase IXβ (BLVRB) is a crucial enzyme in heme metabolism. Recent studies in humans have identified a loss-of-function mutation (Ser111Leu) that unmasks a fundamentally important role in hematopoiesis. We have applied experimental and thermodynamic modeling studies to provide further i...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Chemistry
Main Authors: Chu, Wen-Ting, Nesbitt, Natasha M., Gnatenko, Dmitri V., Li, Zongdong, Zhang, Beibei, Seeliger, Markus A., Browne, Seamus, Mantle, Timothy J., Bahou, Wadie F., Wang, Jin
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293602/
https://ncbi.nlm.nih.gov/pubmed/27897348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201604517
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker