In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency

Heme cytotoxicity is minimized by a two-step catabolic reaction that generates biliverdin (BV) and bilirubin (BR) tetrapyrroles. The second step is regulated by two non-redundant biliverdin reductases (IXα (BLVRA) and IXβ (BLVRB)), which retain isomeric specificity and NAD(P)H-dependent redox coupli...

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Vydáno v:J Biol Chem
Hlavní autoři: Nesbitt, Natasha M., Zheng, Xiliang, Li, Zongdong, Manso, José A., Yen, Wan-Yi, Malone, Lisa E., Ripoll-Rozada, Jorge, Pereira, Pedro José Barbosa, Mantle, Timothy J., Wang, Jin, Bahou, Wadie F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900782/
https://ncbi.nlm.nih.gov/pubmed/29487133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001803
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