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Pre-Clinical Evaluation of Intravenous NAX 810-2, a Novel GalR2-Preferring Analog, for Anticonvulsant Efficacy and Pharmacokinetics
OBJECTIVE: Potential clinical utility of galanin or peptidic analogs has been hindered by poor metabolic stability, lack of brain penetration, and hyperglycemia due to GalR1 receptor activation. NAX 810-2, a GalR2-preferring galanin analog, possesses 15-fold greater affinity for GalR2 over GalR1 and...
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| Udgivet i: | Epilepsia |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5291807/ https://ncbi.nlm.nih.gov/pubmed/28098336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.13647 |
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