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Pre-Clinical Evaluation of Intravenous NAX 810-2, a Novel GalR2-Preferring Analog, for Anticonvulsant Efficacy and Pharmacokinetics

OBJECTIVE: Potential clinical utility of galanin or peptidic analogs has been hindered by poor metabolic stability, lack of brain penetration, and hyperglycemia due to GalR1 receptor activation. NAX 810-2, a GalR2-preferring galanin analog, possesses 15-fold greater affinity for GalR2 over GalR1 and...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Epilepsia
मुख्य लेखकों: Metcalf, Cameron S., Klein, Brian D., McDougle, Daniel R., Zhang, Liuyin, Kaufmann, Dan, Bulaj, Grzegorz, White, H. Steve
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2017
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291807/
https://ncbi.nlm.nih.gov/pubmed/28098336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.13647
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