Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability

IgG isotypes can differentially bind to Fcγ receptors and complement, making the selection of which isotype to pursue for development of a particular therapeutic antibody important in determining the safety and efficacy of the drug. IgG2 and IgG4 isotypes have significantly lower binding affinity to...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Jacobsen, Frederick W., Stevenson, Riki, Li, Cynthia, Salimi-Moosavi, Hossein, Liu, Ling, Wen, Jie, Luo, Quanzhou, Daris, Kristine, Buck, Lynette, Miller, Sterling, Ho, Shu-Yin, Wang, Wei, Chen, Qing, Walker, Kenneth, Wypych, Jette, Narhi, Linda, Gunasekaran, Kannan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290958/
https://ncbi.nlm.nih.gov/pubmed/27994062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748525
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