Pharmacokinetic comparison of a diverse panel of non-targeting human antibodies as matched IgG1 and IgG2 isotypes in rodents and non-human primates

In this study we compared the pharmacokinetic profile of four unrelated antibodies, which do not bind to mammalian antigens, in IgG1 and IgG2 frameworks in both rats and non-human primates (NHP). This allowed for extensive cross comparison of the impact of antibody isotype, complementarity determini...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Walker, Kenneth W., Salimi-Moosavi, Hossein, Arnold, Gregory E., Chen, Qing, Soto, Marcus, Jacobsen, Frederick W., Hui, John
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533040/
https://ncbi.nlm.nih.gov/pubmed/31120944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217061
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