Biological Characterization of a Stable Effector Functionless (SEFL) Monoclonal Antibody Scaffold in Vitro

The stable effector functionLess (SEFL) antibody was designed as an IgG1 antibody with a constant region that lacks the ability to interact with Fcγ receptors. The engineering and stability and pharmacokinetic assessments of the SEFL scaffold is described in the accompanying article (Jacobsen, F. W....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Liu, Ling, Jacobsen, Frederick W., Everds, Nancy, Zhuang, Yao, Yu, Yan Bin, Li, Nianyu, Clark, Darcey, Nguyen, Mai Phuong, Fort, Madeline, Narayanan, Padma, Kim, Kei, Stevenson, Riki, Narhi, Linda, Gunasekaran, Kannan, Bussiere, Jeanine L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290959/
https://ncbi.nlm.nih.gov/pubmed/27994063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748707
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