Biological Characterization of a Stable Effector Functionless (SEFL) Monoclonal Antibody Scaffold in Vitro

The stable effector functionLess (SEFL) antibody was designed as an IgG1 antibody with a constant region that lacks the ability to interact with Fcγ receptors. The engineering and stability and pharmacokinetic assessments of the SEFL scaffold is described in the accompanying article (Jacobsen, F. W....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Liu, Ling, Jacobsen, Frederick W., Everds, Nancy, Zhuang, Yao, Yu, Yan Bin, Li, Nianyu, Clark, Darcey, Nguyen, Mai Phuong, Fort, Madeline, Narayanan, Padma, Kim, Kei, Stevenson, Riki, Narhi, Linda, Gunasekaran, Kannan, Bussiere, Jeanine L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290959/
https://ncbi.nlm.nih.gov/pubmed/27994063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748707
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