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Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability
IgG isotypes can differentially bind to Fcγ receptors and complement, making the selection of which isotype to pursue for development of a particular therapeutic antibody important in determining the safety and efficacy of the drug. IgG2 and IgG4 isotypes have significantly lower binding affinity to...
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Publicado no: | J Biol Chem |
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Main Authors: | , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5290958/ https://ncbi.nlm.nih.gov/pubmed/27994062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748525 |
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