Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability

IgG isotypes can differentially bind to Fcγ receptors and complement, making the selection of which isotype to pursue for development of a particular therapeutic antibody important in determining the safety and efficacy of the drug. IgG2 and IgG4 isotypes have significantly lower binding affinity to...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Jacobsen, Frederick W., Stevenson, Riki, Li, Cynthia, Salimi-Moosavi, Hossein, Liu, Ling, Wen, Jie, Luo, Quanzhou, Daris, Kristine, Buck, Lynette, Miller, Sterling, Ho, Shu-Yin, Wang, Wei, Chen, Qing, Walker, Kenneth, Wypych, Jette, Narhi, Linda, Gunasekaran, Kannan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290958/
https://ncbi.nlm.nih.gov/pubmed/27994062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748525
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