Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP

Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Two small G proteins, Ras and Rap1 have been proposed to mediate this activation. Using HEK293...

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Vydáno v:J Biol Chem
Hlavní autoři: Takahashi, Maho, Li, Yanping, Dillon, Tara J., Stork, Philip J. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270487/
https://ncbi.nlm.nih.gov/pubmed/28003362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.768986
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