Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP

Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Two small G proteins, Ras and Rap1, have been proposed to mediate this activation, with either...

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Vydáno v:J Biol Chem
Hlavní autoři: Li, Yanping, Dillon, Tara J., Takahashi, Maho, Earley, Keith T., Stork, Philip J. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076829/
https://ncbi.nlm.nih.gov/pubmed/27531745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.730978
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