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Ras-mutant Cancer Cells Display B-Raf Binding to Ras That Activates Extracellular Signal-regulated Kinase and Is Inhibited by Protein Kinase A Phosphorylation
The small G protein Ras regulates proliferation through activation of the mitogen-activated protein (MAP) kinase (ERK) cascade. The first step of Ras-dependent activation of ERK signaling is Ras binding to members of the Raf family of MAP kinase kinase kinases, C-Raf and B-Raf. Recently, it has been...
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Główni autorzy: | , , |
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Format: | Artigo |
Język: | Inglês |
Wydane: |
American Society for Biochemistry and Molecular Biology
2013
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779760/ https://ncbi.nlm.nih.gov/pubmed/23893412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463067 |
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